I designed and helped construct an escape room in Denver called "Escape Mars."  It started with a shuttle ride to Mars while the instructions were delivered. Then you spent time in a Mars base looking through the mad journals of the mission astronauts, who had found a Lovecraftian alien menace.  Eventually that had to crawl through a fog soaked tunnel into an alien hatchery.  I challenged myself to ONLY use puzzles I had never seen used before. 

I only have pics of the hatchery, from the portfolio page of Kat Pawlowsky.  She built out 3/4 of that space.  Her work was really impressive.